Computational Biology
Scribe Notes for Class 24
June 23, 2000
Scribe: Chad Wingrave
Today's Handouts and Announcements
- Ayala, Franciso Barrio, Eladio Kwiatowski, Jan "Molecular clock or erratic evolution? A tale of two genes". Proc. Natl. Acad. Sci. vol 93, p 11729-11734, Oct 1996.
Today's Topics
- Stress Response in Plants
- Alscher Early work
- SOD- process that removes troubles from chloroplasts
- found genes that worked on Fe xor Mn
- also found some that worked on Fe and Mn
- Current: Drought response in Loblolly Pine
- Compare kinetic evolution of SOD and Glyceral-3-Phosphate Dehydrogenase (GPDH)
- Molecular Clock
- thought were linear but turns out they are not
- used by phylogenetic field to decide common ancestors ( fossils and observations)
- turns out two different clocks can move at varying rates, and are not always linear
- Using Poisson distribution to model evolution
- poisson - every site changes independently at a common rate
- so given a length of time and a rate, we get the number of expected changes: ne^(-lt) where n is the length of divergence
- so given the number of changes and the rate, we get time: = (-ln q)/2l where q is the probability that neither sequence changed
Today's Sources
- Paper from above (see handouts)
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