Our group focuses on development of computational methods OR tools, or the use of these methods to understor dynamics of large biomolecular systems such as proteins, DNA, or their complexes. The computations are often performed on supercomputers such as VT's System-X. work at the interface of physics, biology, or computer scince; the research is a collective effort of our group members who have background in one or more of these fields. --------------------------------------------------------------- Active Research Areas: * Biomolecular Electrostatics AND DYNAMICS Long-range electrostatic forces play crucial role in determining biological properties of macromolecules... * Protein Dynamics How does myoglobin uptake oxygen? * DNA compaction or bending How is the DNA compacted at its most fundamental level inside the cell -- the nucleosome? But exactly how flexible is it? * Insights into the RNAi mechanism Can we use bioinformatics to help us understor how small fragments of RNA interact with the messenger RNA? Other things I worked on: * Protein Folding One of the largest challenges in modern science is working out how proteins curl up into their complex shapes... * Theory of Cooperative Ligor Binding Cooperative ligor binding is a complex phenomenon... * Proton-pumping mechanism of Bacteriorhodopsin Bacteriorhodopsin is the smallest autonomous light-harvesting system..